Tsuyoshi Imasaki Ph. D.
Kobe University Graduate School of Medicine
Division of Structural Medicine and Anatomy
7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan
Tel: +81-78(382)5324 Fax: +81-78(382)5328
E-mail: ima3 at med.kobe-u.ac.jp
Multi-protein complex formation, structure, and function, In situ structural biology, Drug discovery
2007/03 Ph.D. Science, Yokohama City University International Graduate School of Arts and Sciences, Department of super-molecular biology, Japan
– Subject: Structural basis for substrate recognition and dissociation by human transportin 1
2003/03 MS, Science, Yokohama City University International Graduate School of Arts and Sciences, Department of super-molecular biology, Japan
– Subject: Structural determination of type II restriction endonuclease EcoO109I and its complex with cognate DNA
2001/03 BS, Biochemistry, Yokohama City University, Japan
2018/04 – Present Assistant Professor, Kobe University, Division of Structural Medicine and Anatomy
2014/10 – 2018/03: PRESTO (Japan Science and Technology) researcher at Riken Yokohama (Supervisor: Mikako Shirouzu)
2008/04 – 2011/03: Human Frontier Science Program Long Term Fellow
2007/04 – 2014/03: Postdoctoral research fellow, Indiana University School of Medicine Department of Biochemistry and Molecular Biology (Supervisor: Dr. Yuichiro Takagi)
2008/04 – 2011/03 Human Frontier Science Program Long Term Fellowship.
2005/04 – 2006/03 Yokohama City University, Japan, 21st Century COE Program fellowship.
Major Grant Support:
2022/01 – FOREST (PI) Microtubule based cell polarity in situ
2021/10 – 2027/03 AMED-CREST (Co-investigator) Development of novel antimicrobial adjuvants by innovative compound discovery and synthesis methods
2014/10 – 2018/03 PRESTO (PI)
– Structure determination of Mediator CDK module
2008/04 – 2011/03 Human Frontier Science Program (PI)
– Structural and functional studies on Mediator, central regulatory complex in gene regulation.
The major goal of this project is to determine the structure and identify interacting partner of head module of Mediator